Animal microRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution
Article Abstract:
A large set of genes involved in basic cellular processes avoid microRNA regulation due to short 3'UTRs that are specifically depleted of microRNA binding sites. It showed that for individual microRNAs coexpressed genes avoid microRNA sites, whereas target genes and d are preferentially expressed in neighboring tissues, microRNAs confer accuracy to developmental gene-expression programs, ensuring tissue identity and supporting cell-lineage decisions.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Not miR-ly muscular: microRNAs and muscle development
Article Abstract:
An enormous regulatory potential for microRNA (miRNAs) in gene expression programs, rivaling the complexity of the transcriptional control network is suggested. Understanding the role of miRNAs leads inevitably to the question of why certain gene expression events are targeted by miRNAs rather than by transcriptional repressors.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands
Article Abstract:
The production of two distinct functional microRNAs from opposite DNA strands by a single Hox locus in Drosophila is discussed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2008
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