Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
Article Abstract:
The generation of mice with only 5% the normal levels of N-methyl-D-aspartate (NMDA) receptors were found to exhibit behaviors related to schizophrenia. These behaviors include increased motor activity, stereotypy and social sexual interaction deficits. The schizophrenic behavior were found to be treatable with clozapine or haloperidol, antipsychotic drugs that antagonize serotonergic and dopaminergic receptors.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Beta-Arrestin goes nuclear
Article Abstract:
Arrestin is from a group of proteins that is closely associated with the function of seven transmembrane domain G protein coupled receptors (GPCRs). Evidence shows that beta-arrestine 1 moves to the nucleus in response to GPCR simulation where it regulates gene expression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
Article Abstract:
Study is conducted to show that D2 class-receptor-mediated Akt regulation involves the formation of signaling complexes containing beta-arrestin 2, PP2A, and Akt. Results suggest that beta-arrestin 2 acts as a signaling intermediate through a kinase/phosphatase scaffold.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Probiotics affect virulence-related gene expression in Escherichia coli O157:H7. Kluyveromyces lactis LAC4 promoter variants that lack function in bacteria but retain full function in K. lactis
- Abstracts: In vitro studies on reductive vinyl chloride dehalogenation by an anaerobic mixed culture. Molecular identification of the catabolic vinyl chloride reductase from Dehalococcoides sp. strain VS and its environmental distribution
- Abstracts: Reductive dehalogenase gene expression as a biomarker for physiological activity of Dehaloccoides spp.. Transcriptional expression of the tceA gene in a Dehalococcoides-containing microbial enrichment
- Abstracts: Growth from spores of nonproteolytic Clostridium botulinum in heat-treated vegetable juice. Heterogeneity of times required for germination and outgrowth from single spores of nonproteolytic Clostridium botulinum
- Abstracts: The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord. CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells