Apoptosis in the neuronal lineage of the mouse olfactory epithelium: regulation in vivo and in vitro
Article Abstract:
Cell death in the olfactory epithelium (OE) in normal adult mice is induced by the death of olfactory receptor neurons (ORN) due to removal of the olfactory bulb of the brain. In vivo and in vitro studies on cell death in the OE of the mouse showed that cell death can be inhibited by a variety of agents such as neurotrophins, which prevent cell death in other cells at different developmental stages. These agents alter the time course of cell death in the OE by regulating apoptosis of the cells at multiple stages in the ORN lineage.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Purification of olfactory nerve ensheathing cells from the olfactory bulb
Article Abstract:
A purification procedure for olfactory nerve ensheathing cells from the olfactory bulb was developed. The O4 antibody, which labels many oligodendrocyte-type-2 astrocye (O-2A) progenitors, was used for labeling. O4+ cells that did not express galactocerebroside (GC) exhibited characteristics that resemble O-2A progenitors. However, many O4+GC- cells expressed an antigenic phenotype distinct from other glial populations. These cells were termed olfactory nerve ensheathing cells, representing a novel glial type.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
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Low-affinity NGF-receptor and E-N-CAM expression define two types of olfactory nerve ensheathing cells that share a common lineage
Article Abstract:
A new method using a panel of neural marker antibodies instead of the typical O4 monoclonal antibody was used to compare the antigenic phenotype of purified olfactory nerve ensheathing cells (ONECs) in vitro with that of ONECs in vivo. Using antibodies to polysialic acid and the low-affinity nerve growth factor receptor, immunocytochemical results showed that cells with either phenotype can be generated from a single clonal founder cell.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1996
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