Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation
Article Abstract:
The mRNA-cleavage step of RNA interference is mediated by an endonucleus, argonaute2 (Ago2) within the RNA-induced silencing complex (RISC). The anti-guide strand behaves as a RISC substrate and cleaved by Ago2, which is important for the removal of the anti-guide strand from Ago2 protein and activation of RISC.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Two birds with one stone- Dealing with nuclear transport and spindle assembly
Article Abstract:
Ran-GTP-sensitive interaction of importin beta and its cargo proteins are the simple devices used by the spindle assembly and nuclear transport. A study is carried out, which reports that one of these cargos required for spindle assembly turns out to be Rae1that was known as an mRNA export protein.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Splicing misplaced
Article Abstract:
The presence of functional spliceosomes and signal-dependent pre-mRNA splicing in the cytoplasm of platelets is discussed. Splicing in the cytoplasm is found to be a key regulatory event during platelet activation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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