ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation
Article Abstract:
A reverse genetic approach in mouse epithelial cell line was used to examine the functions of tight junction (TJ) MAGUKs in detail, with special attention to the regulation of the polymerization of claudins. From the TJ strands occurring at apposing membranes and polymerization of claudins at lateral membranes it is concluded that ZO-1 and ZO-2 are indispensable not only for initiating the polymerization of claudins but also for determining where claudins should be polymerized.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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The birnavirus crystal structure reveals structural relationships among icosahedral viruses
Article Abstract:
The crystal structures of the T=1 subviral particle and of the T=13 intact virus particle of an avian birnavirus to 3 angstrom and 7 angstrom resolution, respectively are determined. Results indicate that VP2, the only component of the virus icosahedral capsid, is homologous both to the capsid protein of positive-strand RNA viruses, like the T=3 nodaviruses, and to the T=13 capsid protein of members of the Reoviridae family of double-stranded RNA viruses.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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The HAMP domain structure implies helix rotation in transmembrane signaling
Article Abstract:
A model for the mechanism of signal transduction, in which HAMP alternates between the observed conformation and a canonical coiled coil is explored. Studies show that the equilibrium between the two forms is dependent on the side-chain size of residue 291, which is alanine in the wild-type protein.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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