An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers
Article Abstract:
A new method of grouping alleles, termed the 'delta method,' has been favorably compared with two other, simpler methods for analysis of linkage disequilibrium. The delta method is an attempt to maximize disequilibrium detection with multiallelic markers, by considering information about disequilibrium of individual alleles located adjacently before the alleles are grouped. A reasonable association between physical distance and disequilibrium was found.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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Genomewide scan for linkage reveals evidence of several susceptibility loci for Alopecia areata
Article Abstract:
Genomewide search is performed for linkage in 20 families with Alopecia areata (AA) consisting of 102 affected and 118 unaffected individuals from the United States and Israel to define the genetic basis of AA. The analysis reveals evidence of four susceptibility loci on chromosomes 6, 10, 16 and 18 by use of different statistical approaches.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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