Association analysis of IL1A and IL1B variants in alopecia areata
Article Abstract:
Association analysis of IL1A and IL1B variants is discussed relative to alopecia areata, an inflammatory hair loss disease with a major genetic component. Strong linkage disequilibrium exists between IL1A+ 4845 and IL1B+395. Weak linkage disequilibrium is seen between IL1B-511 and the other two markers. Results suggest possibility of an association with IL1A+4845 in the total dataset but this was not statistically significant. The contribution from mild cases of alopecia areata is a factor, and IL1(alpha) may have a certain role in the pathogenesis of this subgroup.
Publication Name: Heredity
Subject: Biological sciences
ISSN: 0018-067X
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
A unique cause of linkage disequilibrium in natural populations of Drosophila robusta
Article Abstract:
A novel cause of disequilibrium of linkage in natural populations of Drosophila robusta which has been studied in connection with linkage in populations is discussed. Paracentric inversions on the two arms of the metacentric second chromosome are in many cases responsible.
Publication Name: Heredity
Subject: Biological sciences
ISSN: 0018-067X
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Functional analysis of the flagellar genes in the fliD operon of Salmonella typhimurium. The Salmonella FigA protein, a putative periplasmic chaperone essential for flagellar P ring formation
- Abstracts: Molecular cloning and analysis of the ptsHI operon in Lactobacillus sake. Development of genetic tools for Lactobacillus sakei: disruption of the beta-galactosidase gene and use of lacZ as a reporter gene to study regulation of the putative copper ATPase, AtkB
- Abstracts: Reverse transcription-PCR analysis of the regulation of the manganese peroxidase gene family. The green fluorescent protein gene functions as a reporter of gene expression in Phanerochaete chrysosporium
- Abstracts: Molecular analysis of the DNA gyrB gene from Myxococcus xanthus. Emulsifying activities of purified alasan proteins from Acinetobacter radioresistens KA53
- Abstracts: Genetic analysis of sneaking and egg-thievery in a natural population of the three-spined stickleback (Gasterosteus aculeatus L.)