Associative overdominance, heterozygosity and fitness
Article Abstract:
Researchers investigated the power of associative overdominance in creating a correlation between individual heterozygosity and fitness and in maintaining genetic polymorphism at neutral loci. This was done by simulating a diploid model with five chromosomes. Various combinations such as population size, number of crossovers, selection coefficient, and dominance were used. All combination of parameter values resulted in positive regression, even though fitness differences were not large. The link between individual heterozygosity and fitness was clear for recessive mutations. The results showed that associative overdominance could help maintain polymorphisms in small populations.
Publication Name: Heredity
Subject: Biological sciences
ISSN: 0018-067X
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Are polymorphism and evolutionary rate of allozyme proteins limited by mutation or selection?
Article Abstract:
A computer simulation suggests that mutation rather than selection is more likely to control the polymorphism and evolutionary rate of allozyme proteins. The range of models that can account for the variation in allozyme heterozygosity and genetic distance through type or intensity of selection is fairly narrow, whereas mutation rate can more easily explain the variation through a wider range of models.
Publication Name: Heredity
Subject: Biological sciences
ISSN: 0018-067X
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice. Insulin secretion: SIRT4 gets in on the act
- Abstracts: A putative integrase gene defines the distal end of a large cluster of ToxR-regulated colonization genes in Vibrio cholerae
- Abstracts: A chitin-binding domain in a marine bacterial chitinase and other microbial chitinases: implications for the ecology and evolution of 1,4-beta-glycanases
- Abstracts: Rad52 associates with RPA and functions with Rad55 and Rad57 to assemble meiotic recombination complexes. PTB/nPTB switch: A post-transcriptional mechanism for programming neuronal differentiation
- Abstracts: New perspectives on mate choice and the MHC. Reaction norm functions and QTL--environment interactions for flowering time in Arabidopsis thaliana