Regulation through the secondary channel-structural framework for ppGpp-DksA synergism during transcription
Article Abstract:
A study is conducted to show that the DksA protein is a crucial component of ppGpp-dependent regulation. Biochemical analysis demonstrates that DksA affects transcript elongation, albeit differently from GreA, augments ppGpp effects on initiation and binds directly to RNAP, positioning the Asp residues near the active site.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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REG(gamma): A shortcut to destruction
Article Abstract:
Destruction of intact cellular proteins are largely orchestrated by ATP-dependent ubiquitination and subsequent degradation by the 26S proteasome. The proteasomal activator REG(gamma) directs degradation of the steroid receptor coactivator SRC-3 by the 20S proteasome in an ATP- and ubiquitin-independent manner.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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