CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome

Article Abstract:

Mutations in the CSA or CSB complementation genes cause the Cockayne syndrome, a severe genetic disorder that results in patients' death in early adulthood. Following UV irradiation, CSB is degraded at a late stage of the repair process in a proteasome- and CSA-dependent manner. The importance of CSB degradation for post-transcription-coupled repair (TCR) recovery of transcription and for the Cockayne syndrome is demonstrated, which unravel for the first time the functional relationship between CSA and CSB.

United States, Science & research, Genetic aspects, DNA damage, Cockayne syndrome, Ubiquitin-proteasome system

---

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and elF3

Article Abstract:

A study was conducted on two subcomplexes, the lid and the base, of the proteasome regulatory particle. Results showed that the base suffices the activation of the core particle for degradation of peptides or a nonubiquitinated protein, while the lid is needed for ubiquitin-dependent degradation. Moreover, the lid subunits have similar sequence motifs with components of the COP9/signalosome and elF3.

Proteases, Proteins, Ubiquitin

---

Similar abstracts:

• Abstracts: A role for the deubiquinating enzyme USP28 in control of the DNA-damage response. Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints
• Abstracts: Light-dependent degradation of nitrophenols by the phototrophic bacterium Rhodobacter capsulatus E1F1. Characterization of a nitrophenol reductase from the phototrophic bacterium Rhodobacter capsulatus E1F1
• Abstracts: Construction of a chickpea linkage map and its comparison with maps of pea and lentil. Linkage of loci encoding H1 histone and a cotyledon protein in lentil
• Abstracts: Propagation of prions with artificial properties in transgenic mice expressingchimeric PrP genes. Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
• Abstracts: Sumo-mediated regulation of synaptonemal complex formation during meiosis. Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.