Where the cell cycle and histones meet
Article Abstract:
Understanding of cyclin E-CDK2 has been enlarged and is discussed in this perspective article. It has been shown that NPAT, a CDK2 substrate, links the cell cycle to histone gene transcription. The new information gives a view of how the action of CDKs is linked to the periodic synthesis of histones in mammalian cells. The way in which cell cycle control elements may influence multiple biosynthetic processes as integral to S phase as duplication of the genetic material itself is now more apparent. CDK2 substrates seem to be many. The principle mediators of cyclin E-CDK2 action are not yet identified.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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Cell cycle-regulated phosphorylation of p220(super.NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription
Article Abstract:
Cell cycle-regulated phosphorylation of p220(super.NPAT) by cyclin E/Cdk2 in Cajal bodies has been shown to promote histone gene transcription. In investigation of how cyclin E/Cdk2 controls S-phase events, the subcellular localization of the cyclin E/Cdk2 interacting protein p220(super.NPAT) and its regulation by phosphorylation was studied, and it was found that p220 is localized to discrete nuclear foci. Five cyclin E/Cdk2 phosphorylation sites in p220 were found.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation
Article Abstract:
Binding of c-Myc to chromatin has been found to mediate mitogen-induced acetylation of histone H4 and gene activation. Chromatin immunoprecipitation (ChIP) was used to study Myc-dependent changes in histone acetylation at target loci. Myc seems to be a permissive factor that allows other signals to activate target promoters.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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