CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP
Article Abstract:
An essential pacemaker component called CLOCK controls expression of DBP, a circadian transcription factor. DBP is the initial member of the PAR leucine zipper transcription factor group. DBP has a role in regulation of several clock outputs. It has been shown that circadian Dbp transcription must have the basic helix-loop-helix-PAS protein CLOCK which is necessary in negative-feedback circuitry that brings on circadian oscillations in fruit flies and mammals.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Article Abstract:
Restricted feeding under light-dark or dark-dark conditions has been found to uncouple circadian oscillators in peripheral tissues so that they are not connected to the central pacemaker, which is in the suprachiasmatic nucleus (SCN). Mice, nocturnal animals, when fed only in the day, will have the phase of circadian oscillators in peripheral cells inverted. There is little effect, if any, on the central oscillator in the suprachiasmatic nucleus. Feeding-time-induced uncoupling of circadian phases in peripheral cells and SCN neurons is not explained by a dominant Zeitgeber effect of light in the SCN.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation
Article Abstract:
Locations of the Drosophila melanogaster homologs of Spt5 and Spt6 proteins were studied on heat shock genes in vivo at both high and low resolution. Their roles in promoter proximal pausing and transcription elongation were considered. A role for Spt5 in regulating heat shock gene pausing and activation is proposed. Roles for both proteins in transcriptional elongation are proposed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
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