Developmentally induced changes in transcriptional program alter spatial organization across chromosomes
Article Abstract:
The changes in nuclear organization accompanying stimulus by the mating pheromone alpha factor of the Saccharomyces cerevisiae is examined. The results reveal RNA- and DNA-dependent determinants of nuclear organization and a detailed picture of how an entire chromosome alters its spatial conformation in response to a developmental cue.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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Regulation of transcription factor latency by receptor-activated proteolysis
Article Abstract:
The mechanism responsible for the amino acid-induced processing of the transcription factor stp1 is pursued in response to extracellular amino acids by the plasma membrane SPS (Ssy1-Ptr3-Ssy5)-sensor. The results demonstrate that regulating the enzymatic activity of an intracellular endoprotease could control gene expression.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
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