Cleavage plane specification in C. elegans: how to divide the spoils
Article Abstract:
Cleavage plane formation in Caenorhabditis elegans embryo have been found to be controlled by the par and mes-1 genes. The two genes act to regulate the rotational alignment of the centrosomes and the alignment of the mitotic apparatus (MA). Rotational alignment of the MA depends upon the structure of the actin cytoskeleton. The actin cytoskeleton also governs the segregation of the P granules. The structure of the microtubules also act to direct the migration of the MA to their respective positions during mitosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Determination of cleavage planes
Article Abstract:
Proper cell division requires precision not only in chromosome segregation but also in the subsequent cleavage of the cell into two daughter cells. The position of the cleavage plane is ultimately determined by the position of the mitotic spindle. Current knowledge in the control of spindle orientation, control of spindle assymetry and the roles of actin cytoskeleton, microtubules and other cell organelles in nuclear and spindle movements are discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans
Article Abstract:
A study showed that the PGL-1, a predicted RNA-binding component of germ granules, is necessary for fertility in Caenorhabditis elegans. The finding is based on molecular and genetic analyses of PGL-1. The analyses revealed that defective granules and sterility resulted from the elimination of PGL-1. It was also found that the PGL-1 function is needed for fertility only at raised temperatures.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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