Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
Article Abstract:
It has been shown that p53 and ARF potentiate Myc-induced apoptosis in primary pre-B-cell cultures. Spontaneous inactivation of the ARF-Mdm2-p53 pathway is frequent in tumors in E-mu-myc transgenic mice. Myc activation selects strongly for spontaneous inactivation of the ARF-Mdm2-p53 pathway in vivo. It cancels the protective checkpoint function and speeds progress to malignancy.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines
Article Abstract:
The authors analyzes the study on cell survival regulation. The topics of interest include the role of serine/threonine kinase Pim-2 in growth factor-mediated apoptotic resistance in hematopoeitic cells.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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