Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor
Article Abstract:
The mechanism by which the Salmonella PmrA/PmrB two-component system responds to the signal controlling the PhoP/PhoQ two-component system is reported. The PhoP-activated PmrD protein binds to the phosphorylated form of the response regulator PmrA, preventing both its intrinsic dephosphoylation promoted by its cognate sensor kinase PmrB.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p
Article Abstract:
Saccharomyces cerevisiae kinetochores are regulated by a type 1 phosphatase, Glc7p. The microtubule-binding activity of the kinetochore complex is controlled by a balance between a protein kinase and the type 1 protein phosphatase (PP1) coded for in the GLC7 gene. The centromeric DNA-binding activity is not so regulated.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Ipl 1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores
Article Abstract:
The chromosomes get wrongly attached to the microtubules due to the lack of sufficient tension between the sister chromatids. The phosphorylation of a checkpoint protein Mad3p by Ipl1protein kinase is essential for restoring the kinetochore tension and correction of chromosome binding to microtubules.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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