Mitotic remodeling of the replicon and chromosome structure
Article Abstract:
Animal cloning by nuclear-transfer experiments fails frequently due to inability of transplanted nuclei to support normal embryonic development. Results indicate that mitotic conditioning is crucial to reset the chromatin structure of differentiated adult donor cells from embryonic DNA replication.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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MCM8 is a MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation
Article Abstract:
The MCM2-7-related protein MCM8 is required to efficiently replicate chromosomal DNA in Xenopus egg extracts. Reconstitution experiments show that ATP binding in MCM8 is required to rescue DNA synthesis in MCM8-depleted extracts.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
MCM8 is a MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation
Article Abstract:
The MCM2-7-related protein MCM8 is required to efficiently replicate chromosomal DNA in Xenopus egg extracts. Reconstitution experiments show that ATP binding in MCM8 is required to rescue DNA synthesis in MCM8-depleted extracts.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
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