The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors
Article Abstract:
Biochemical and biophysical analyses of KIF1A, a class of kinesin superfamily proteins, revealed a monomeric, globular molecule with an anterograde motor velocity of 1.2 micrometer/second. Analysis of membranous organelles isolated from the axon indicated KIF1A's association with organelles containing synaptic vesicle proteins. However, these organelles contained various SV proteins and not the known anterograde proteins. This suggests that the membrane proteins are sorted into different transport organelles and are transported by specific motor proteins through the axon.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity
Article Abstract:
Apoptosis is a physiological process that controls the final numbers of neurons in brain development, and the activity-dependent prevention of apoptosis in juvenile neurons is regulated by kinesin superfamily protein 4 (KIF4), a microtubule-based molecular motor. It is suggested that KIF4 controls the activity-dependent survival of postmitotic neurons by regulating Polymerase-1 (PARP-1) activity in brain development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Mechanism of nodal flow: A conserved symmetry breaking event in left-right axis determination
Article Abstract:
Rabbit and medakafish embryos exhibit a leftward fluid flow in their ventral nodes. This leftward flow might produce asymmetric distribution of exogenously introduced proteins, suggesting morphogen gradients as a subsequent mechanism of left-right axis determination.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
- Abstracts: Probing in vivo promoter activities in Mycoplasma pneumoniae: A system for generation of single-copy reporter constructs
- Abstracts: The Bifidobacterium longum NCIMB 702259(super T) ctr gene codes for a novel cholate transporter. part 2 Identification and characterization of a fructose phosphotransferase system in Bifidobacterium breve UCC2003
- Abstracts: Global carbon utilization profiles of wild-type, mutant, and transformant strains of Hypocrea jecorina. Role of the bga1-encoded extracellular beta-galactosidase of hypocrea jecorina in cellulase induction by lactose
- Abstracts: Group-specific 16S rRNA-targeted oligonucleotide probes to identify thermophilic bacteria in marine hydrothermal vents