Conservation and antigenic cross-reactivity of the transferrin-binding proteins of Haemophilus influenzae, Actinobacillus pleuropneumoniae and Neisseria meningitidis
Article Abstract:
The transferrin-binding proteins (Tbps) of Haemophilus influenzae, Actinobacillus pleuropneumoniae and Neisseria meningitidis have shared epitopes, despite their transferrin species specificity. Screening of the human sera for the presence of cross-reactive antibodies to the Tbps revealed that sera from healthy adults contained antibodies which recognized both Tbp1 and Tbp2 from H. influenzae but not N. meningitidis. Convalescent sera from patients recovering from Haemophilus or meningococcal meningitis contained antibodies which recognized the Tbps2s of both pathogens on Western blots.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Sequence, genetic analysis, and expression of Actinobacillus pleuropneumoniae transferrin receptor genes
Article Abstract:
The transcription of transferrin receptor genes tbpA and tbpB of Actinobacillus pleuropneumoniae, present in an operon, is controlled by one promoter. The structure of Tbp1 protein, encoded by tbpA, is similar to that of Lbp and Tbp1s proteins of Neisseria and the outer membrane (OM) receptors of Escherichia coil. Most of the recombinant Tbp1 formed by tbpA overexpression is present in the inclusion bodies while most of the recombinant Tbp2, encoded by tbpB, is present in the OM region. Both Tbp1 and Tbp2 bind to the C region of porcine transferrin.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
The staphylococcus aureus and Staphylococcus epidermidis transferrin-binding proteins are expressed in vivo during infection
Article Abstract:
A cell wall associated protein in Staphylococcus aureus and S. epidermidis preferentially binds transferrin. This protein is expressed by this organisms in vivo during infection as determined from in vivo studies using mice. Further, antibodies against this protein has been identified among dialysis patients. Competitive binding assays have proven the specific binding affinity of this protein to transferrin.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Identification and characterization of homeobox transcription factor genes in strongylocentrotus purpuratus, and their expression in embryonic development
- Abstracts: Phylogenetic analyses of the homologous transmembrane channel-forming proteins of the F0F1-ATPases of bacteria, chloroplasts and mitochondria
- Abstracts: Effect of pasteurization on infectivity of Cryptosporidium parvum oocysts in water and milk. In vitro interactions of Asian freshwater clam (Corbicula fluminea) hemocytes and Cryptosporidium parvum oocysts
- Abstracts: Integrated mapping and sequencing of a 115 kb DNA fragment from Bacillus subtilis: sequence analysis of a 21 kb segment containing the sigL locus
- Abstracts: Identification of vegetative proteins for a two-dimensional protein index of Bacillus subtilis. Phosphate-starvation-inducible proteins in Bacillus subtilis; a two-dimensional gel electrophoresis study