Control of the assembly of ATP- and ADP-Actin by formins and profilin
Article Abstract:
A study suggested that profilin and ATP hydrolysis are both required for processive elongation mediated by the formin mDia1. Total internal reflection fluorescence microscopy is used to observe directly individual actin filament polymerization in the presence of two mammalian formins (mDia1 and mDia2) and two yeast formins (Bni1p and Cdc12p).
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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The beta-thymosin/WH2 domain: structural basis for the switch from inhibition to promotion of actin assembly
Article Abstract:
The beta-thymosin/WH2 domain has versatile regulatory properties in actin dynamics and motility. A combined biochemical functional and structural approach is used to explain the basis for the switch of a G actin binding domain from assembly inhibition to assembly promotion.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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