CDK inhibitors: positive and negative regulators of G(sub.1)-phase progression
Article Abstract:
Cyclin-dependent kinase (CDK) inhibitors (CKIs) are positive and negative regulators of first gap phase (G(sub.1)-phase) progression. CKIs are required for cyclin D-CDK assembly and INK4 proteins are dependent on Cip/Kip proteins to bring on G(sub.1)-phase arrest. The major role of the D-type cylins is as growth factor sensors. They convert environmental signals to fuel to run the cell cycle engine. The necessity of cyclin D-dependent kinase activity for the cell cycle and a role for Cip/Kip proteins in cancer are discussed and current literature is reviewed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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PPAR delta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
Article Abstract:
PPAR delta, which is in the nuclear receptor superfamily, is discussed as an APC-regulated target of nonsteroidal anti-inflammatories (NSAIDs). PPAR delta was found to be a target of APC in analysis of global gene expression profiles in human colorectal cancer cells. It is likely that NSAIDs inhibit tumorigenesis by inhibition of PPAR delta. Its gene is usually regulated by APC.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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