CBP/p300 in cell growth, transformation, and development
Article Abstract:
CREB binding protein (CBP) and p300 and the complexes processes they participate in in cell growth, development, and transformation are discussed in this review article. The two proteins seem to be able to contribute to diametrically opposed cellular processes. They work in various tumor-suppressor pathways. They are also, as coactivators, essential for functions of many oncogenes. Whether they are part of apoptosis or cell proliferation seems to be very context-dependent.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Sequential actions of BMP receptors control neural precursor cell production and fate
Article Abstract:
Sequential actions of bone morphogenetic proteins (BMP) receptors have been found to regulate neural precursor cell production and fate. A feed-forward mechanism is described, and it clarifies how the sequential actions of receptors control production and fate of dorsal precursor cells from neural stem cells. Expression/function of two BMP receptors, BMPR-IA and BNPR-IB, in neural precursor cells was studied in vivo and in vitro.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Transformation of myeloid progenitors by MLL oncoproteins is dependent in Hoxa7 and Hoxa9
Article Abstract:
Research has been conducted on myeloid progenitors. The authors report that these progenitors immortalized by MLL oncoproteins possess Hoxa gene cluster expression profile.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Short-range and long-range guidance by slit and its Robo receptors: A combinatorial code of robo receptors controls lateral position
- Abstracts: Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation
- Abstracts: Fortified sera and their use in environmental virology. Influence of salts on virus adsorption to microporous filters
- Abstracts: Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate
- Abstracts: Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca(super.2+) channels