Chk1 is an essential kinase that is regulated by Atr and required for the G(sub.2)/M DNA damage checkpoint
Article Abstract:
Chk1 has been found to be an essential kinase. It is evolutionarily conserved, regulated by Atr and is necessary for the G(sub.2)/M DNA damage checkpoint to function. It is thus essential in embryonic development and tumor suppression.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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Double-strand end repair via the RecBC pathway in Escherichia coli primes DNA replication
Article Abstract:
Studies indicate a circular relationship between DNA recombination and replication in Escherichia coli experiments. By monitoring phage lambda chromosomes, researchers determined that the E. coli RecBC pathway employs double-strand ends to foster DNA synthesis, which in turn produces double-strand ends. This suggests that recombination's primary role is repairing disintegrated replication forks.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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