Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes
Article Abstract:
The role of cGKII as a molecular switch, coupling the cessation of proliferation and the start of hypertrophic differentiation of chondrocytes through attenuation of Sox9 function is studied. The cGKII attenuated the Sox9 functions to induce the chondrogenic differentiation and to inhibit the hypertrophic differentiation of chondrocytes and the attenuation of Sox9 was due to the cGKII inhibition of nuclear energy.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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Essential and separable roles for syndecan-3 and syndecan-4 in skeletal muscle development and regeneration
Article Abstract:
Syndecan-3(super -/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells. The data reveals that the surrounding environmental is critical for satellite cell proliferation and differentiation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
User Contributions:
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