cAMP-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape
Article Abstract:
Cyclic adenosine monophosphate (cAMP)/ cAMP-dependent protein kinase A (PKA)- mediated signaling routes are significant in supporting the motility, survival, proliferation and differentiation of epithelial cells. An analysis of the progressive development about the role of cAMP/PKA in regulating the intracellular membrane trafficking with respect to the dynamics of epithelial surface domains is presented.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2008
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Scaffold proteins in MAP kinase signaling: More than simple passive activating platforms
Article Abstract:
A study to shortly summarize the well-established basic functions of Scaffold in yeast highlight concepts emerging from studies in yeast and higher eukaryotes was conducted. The results discuss how scaffolds conformational changes of bound kinase or substrate, by controlling the localization of activated mitogen-activated protein kinase (MAPK) and the extent and output of MAPK activation.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2006
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Non-kinase second-messenger signaling: new pathways with new promise
Article Abstract:
Second messenger molecules function as activators of dedicated protein kinases that, in turn, activate downstream kinase cascades. The four-prototypical second messengers such as cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), diacylglycerol (DAG) and calcium are described.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2004
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- Abstracts: Segregation of storage protein mRNAs on the rough endoplasmic reticulum membranes of rice endosperm cells. A second signal recognition event required for translocation into the endoplasmic reticulum
- Abstracts: FGF-dependent Notch signaling maintains the spinal cord stem zone. Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling
- Abstracts: When specialized sites are important for synapsis and the distribution of crossovers. Endogenous inhibitors of RNA interference in Caenorhabditis elegans