Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta

Article Abstract:

Cyclo-oxygenase-2(COX2)-derived prostacyclin (PGI(sub.2)) is helpful to embryo implantation in the mouse through PPARdelta. PGI(sub.2) is the main prostaglandin (PG) essential for implantation and decidualization. It appears from various lines of evidence, that effects of PGI(sub.2) are mediated by activation of the nuclear hormone receptor PPARdelta. This is the first reported biologic function of that receptor signaling route. It has been shown that COX2, rate-limiting enzyme in the biosynthesis of PGs, is required for decidualization and for blastocyst implantation. Mechanism and candidate PGs for participation have not been known.

Research, Prostaglandins, Mice, mutant strains, Mutant mice, Embryology, Experimental, Embryological research, Ovum implantation, Blastocyst

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NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism

Article Abstract:

Research shows that the nuclear factor kappa B (NF-kappaB) modulates mesenchymal-derived cell lineage differentiation through posttranscriptional down regulation of developmental regulators in response to cytokine signaling. Furthermore, it inhibits chondrogenesis and destabilizes transcription factor Sox9 mRNA.

Cell differentiation, Cell nuclei, Cell nucleus

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Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis

Article Abstract:

Research shows that beta1-integrin mutant chondrocytes fail to form columns during growth, exhibit marked proliferation defects that affect several phases of the cell cycle. Results demonstrate that beta1-integrin-dependent motility and chondryocyte proliferation are essential for endochondral bone formation.

Germany, Switzerland, Integrins, Osteogenesis

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