DNA damage and checkpoint pathways: molecular anatomy and interactions with repair
Article Abstract:
The three main issues addressed by several studies on DNA damage and replication checkpoints are discussed. The first involves the basic molecular anatomy of the checkpoint protein interaction that is responsible for the signal arrest and transcriptional induction of repair genes, The second concerns several interactions between checkpoint controls and DNA repair and replication. The last concerns the roles of checkpoints in preserving genomic stability.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
Article Abstract:
DNA nonhomologous end-joining (NHEJ) is a predominant pathway of DNA double-strand break repair in mammalian cells, and defects in it cause radiosensitivity at the cellular and whole-organism levels. It is shown that XRCC4-like factor (XLF) directly interacts with the XRCC4-Ligasse IV complex in vitro and vivo and that siRNAA-mediated down regulation of XLF in human cell lines leads to radiosensitivity and impaired NHEJ.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
HnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage
Article Abstract:
A study was conducted in response to DNA damage where mammalian cells trigger the p53 dependent transcriptional induction of factors that regulate DNA repair, cell-cycle progression, or cell survival. The results showed heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a new HDM2 target and plays key roles in coordinating transcriptional responses to DNA damage by serving as a cofactor for p53.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Response: Cellular uptake of sex steroid hormones
- Abstracts: Potential role of pathogen signaling in multitrophic plant-microbe interactions involved in disease protection
- Abstracts: A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Hematopoietic stem cell fate is established by the Notch-Runx pathway
- Abstracts: The Homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Homeobox galore: When reproduction goes RHOX and Roll
- Abstracts: Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs. Red-Hed regulation: Recombinase Rad51, though capable of playing the leading role, may be relegated to supporting Dmc1 in budding meiosis