An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3
Article Abstract:
Steroid hormones penetrate cells by diffusion through the plasma membrane. However, it was observed that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes. It was also discovered that 25-(OH) vitamin D3 in complex with its plasma carrier, the vitamin D-binding protein, is filtered through the glomerulus and reabsorved in the proximal tubules by the endocytic receptor megalin.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Response: Cellular uptake of sex steroid hormones
Article Abstract:
The role of megalin, an endocytic receptor of the low-density lipoprotein (LDL) receptor gene family, in reproductive tissues is discussed. Impaired development of male and female reproductive tissues and sex steroid insensitivity is a result of deficiency in the megalin receptor.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Two distinct pathways for trehalose assimilation in the yeast saccharomyces cerevisiae. Saccharomyces cerevisiae JEN1 promoter activity is inversely related to concentration of repressing sugar
- Abstracts: Double-layer plague assay for quantification of enteroviruses. Enteroviruses and bacteriophages in bathing waters
- Abstracts: Replication termination in Escherichia coli: Structure and antihelicase activity of the Tus-Ter complex. Discontinuous or semi-discontinuous DNA replication in Escherichia coli?
- Abstracts: Role of endocytosis in cellular uptake of sex steroids. Sex steroids and the free hormone hypothesis. "Bound" to work: The free hormone hypothesis revisited
- Abstracts: Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Histone lysine demethylases and their impact on epigenetics