Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse

Article Abstract:

The scrapie incubation time phenotype in mice having chromosomes with meiotic crossovers near Prn-p was determined. Analysis showed the gene Prn-i, which was positioned 0.22 cM distal and 0.67 proximal to Prn-p, controlled the interval between inoculation and illness in experimental mouse scrapie. The results also showed that the influence of Prn-p (sub b) expression on shortening the incubation was decreased when the transgene was transferred to mice with long incubation time allele. The study implied that Prn-i and Prn-p (sub b) transgenes controlled different scrapie pathogenetic mechanisms.

Prions, Prions (Proteins), Scrapie

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A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice

Article Abstract:

The insertional mutations in genes are screened by mouse embryonic stem (ES) cells and a gene trap vector. The screening involves the developmental regulation of the genes at 8.5 days of embryogenesis. The screening reveals that the active transcription units are disrupted by the 393 clonal integrations of the 38,730 cell lines having vector integrations.

Mutation (Biology), Mutation, Heredity

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