Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling
Article Abstract:
The development of sense organs requires the ectodermal cellular process involving enhancers and proneural proteins. The enhancers promote proneural protein accumulation in ectodermal cells and mediate self-stimulation. Other cells are exempt from this process due to the Notch signaling, which blocks the self-stimulation activity by antagonizing the enhancer action on the proteins.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation
Article Abstract:
A study is undertaken to observe the importance of glutamatergic synapses for shaping neural circuits for development. Findings reveal that MTG is secreted from the presynaptic terminal to shape the extracellular synaptic cleft domain, which in turn functions to mediate transynaptic signals required for post-synaptic development.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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