Detrimental deletions: Mitochondria, aging and Parkinson's disease
Article Abstract:
Clear evidence for a high burden of mitochondrial DNA deletions within substantia nigra neuros in aged individuals and individuals with Parkinson's disease (PD) is presented pointing towards a common pathway inevitably leading to neuronal dysfunction and death. It is suggested that mitochondrial DNA (mtDNA) deletions expand clonally within individual substantia nigra neurons over time where they can exceed the phenotypic threshold of 60% of mitochondrial DNA (mtDNA).
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2006
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Coevolution theory of the genetic code at age thirty
Article Abstract:
The coevolution theory of the genetic code has four fundamental tenets comprising the essentiality of amino acid biosynthesis, role of pretran synthesis, biosynthetic imprint on codon allocations and mutability of the encoded amino acids. The utility of the co evolution is demonstrated by its experimental expansions of the code and providing a basis for locating the root of life.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
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