Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
Article Abstract:
A study was conducted to analyze the association between receptor tyrosine kinase activated signaling pathways and the transcriptional induction of immediate early genes. Global expression monitoring was utilized to identify 66 fibroblast immediate early genes induced by platelet-derived growth factor beta receptor signaling. Results indicated that diverse pathways promote overlapping effects on gene induction.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
Article Abstract:
DNA probes revealed that PDGF activates inactive serine/threonine protein kinase encoded by Akt proto-oncogenes. The Akt activation was shown to be accompanied by mutations in tha Akt Pleckstrin domain and dependent on PDGFbeta tyrosines Y740 and Y751, which binds to phosphatidylinositol 3-kinase. Howver, activation was blocked by inhibitory proteins led by PI 3-kinase inhibitor wortmannin and other N17Ras.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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PI3K: downstream AKTion blocks apoptosis
Article Abstract:
The function of phosphoinositide 3-kinase (PI3K) in intracellular signaling has been underscored by its implication in a wide array of biological responses. One of the more recent findings indicates that PI3K is involved in providing cellular protection against programed cell death or apoptosis through a signaling pathway that involves the serine\threonine protein kinase Akt/PKB.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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- Abstracts: Gene families encoding transcription factors expressed in early development of Strongylocentrotus purpuratus. Identification and developmental expression of the ets gene family in the sea urchin (strongylocentrotus purpuratus)
- Abstracts: Half-tetrad analysis in zebrafish: mapping the ros mutation and the centromere of Linkage Group I. Genetic control of adult pigment stripe development in zebrafish
- Abstracts: Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Identification of a nuclear receptor that is activated by farnesol metabolites