Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
Article Abstract:
A study revealed that Drosophila conserved eukaryotic gene fizzy-related regulates cyclin A, B and B3 levels negatively. The cdk1 binding and activating mitotic cyclins were found to degrade rapidly during G1 and when exiting from M. Results also show that fizzy-related loss induces salivary gland endoreduplication inhibition as well as progression through an additional division cycle in the epidermis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Identification of a Stat gene that functions in Drosophila development
Article Abstract:
A Drosophila Stat gene was identified. This gene encodes the signal transducers and activators of transcription (STAT) proteins, which function in cellular signal transduction and activate transcription. Phosphorylation studies showed that this STATs play an important role in segmental pattern formation during Drosophila early development by activating specific stripes of pair rule gene expression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Independent regulation of synaptic size and activity by the anaphase-promoting complex
Article Abstract:
A novel postmitotic role for the anaphase-promoting complex/cyclosome (APC/C) at Drosophila neuromuscular synapses is described. In neurons, the APC/C controls synaptic size through a downstream effector Liprin-alpha, and in muscles it controls the concentration of a postsynaptic glutamate receptor.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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- Abstracts: Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
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- Abstracts: Two heads are better than one: regulation of DNA replication by hexameric helicases. SUMO and ubiquitin in the nucleus: different functions, similar mechanism?
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