Ectopic expression of the flagellar regulon alters development of the Bordetella-host interaction
Article Abstract:
Evaluation of the motility control facilitated by the Bordetella virulence control locus, bvgAS, and the variation in the genetic circuity helps study the function of negative control by BvgAS in the environment of Bordetella in a host. frlAB, the regulatory locus that is essential for flagellar organelle synthesis is negatively regulated by BvgAS. frl expression pattern reversal stimulates motility in the Bvg+ growth phase. Reduction in the colonization by Bordetella bronchisptica due to the ectopic expression of frl at the time of onset of respiratory infection reveals that both positive and negative regulation by BvgAS are essential during colonization.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity
Article Abstract:
Research was conducted to study the effects of bacterial antigen compartmentalization on in vivo priming of CD8 T cells and protective immunity against bacterial infection. DNA sequences and signal sequence were amplified by polymerase chain reaction while Listeria monocytogene cultures were growth in brain heart infusion. Results indicated that recombinant strains expressed either a secreted or nonsecreted form of a model CD8 T cell epitope and can influence epitope-specific CD8 T cell responses.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
Article Abstract:
Impaired bactericidal activity of airway surface fluid in cystic fibrosis (CF) patients is caused by defective Cl transport across airway epithelia. Bactericidal activity in normal airway surface fluid depends on a low salt concentration. In CF epithelia, however, loss of the phosphorylation-regulated Cl channels results in an abnormally high salt concentration in the airway surface fluid, which reduces bactericidal activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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- Abstracts: Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart
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