Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden

Article Abstract:

Genetic mapping for type 1 diabetes (T1D) was performed using single-nucleotide polymorphism (SNP) markers in the 4.4-Mb human major histocompatibility complex (MHC) locus in a survey of Swedish T1D cases and controls. A peak of association within the inositol 1,4,5-triphosphate receptor 3 gene (ITPR3) is identified in the region centromeric to the MHC, and the estimated population-attributable risk suggests that variation within ITPR3 reflects an important contribution to T1D in Sweden.

Science & research, Industrial Organic Chemicals, Cyclic Crude and Intermediate Manufacturing, Inositol, Diagnosis, Risk factors, Type 1 diabetes, Chromosome mapping, Nucleotide sequencing

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Analysis of chromosome 1q42.2-43 in 152 families with high risk of prostate cancer

Article Abstract:

Research attempting to link a chromosome locus to prostate cancer is inconclusive. In parametric and nonparametric testing of 152 families prone to prostate cancer, positive links were not found, even when subjects were stratified into subsets based on mean diagnosis age. A small degree of linkage was discovered among families with a minimum of five affected men.

United States, Prostate cancer, Chromosome abnormalities, Prostate diseases, Prostatic diseases

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