Evolutionary conservation of cell migration genes: From nematode neurons to vertebrate neural crest

Article Abstract:

Comparative genomic analysis was performed to explore the genetic networks involved in long-range cell migrations that are conserved across the large evolutionary distance between Caenoryhabditis elegans hermaphrodite specific neurons (HSN) and vertebrate neural crest cells. The results demonstrate that the neural crest, a uniquely vertebrate cell type, shares common regulatory elements for cell migration programs utilized in the nematode suggesting that the role of these genes was present in the common ancestor of vertebrates and invertebrates.

Vertebrates, Developmental genetics, Neurogenetics, Cell migration

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Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway

Article Abstract:

The analysis of the cis-acting sequences and trans-acting factors required in for nonsense-mediated mRNA decay (NMD) in Caenorhabditis elegans is used to investigate the mechanistic insights and identify two new novel factors in the substance. The spotted two genes are used for the purpose of proper embryonic development, as the proteins required in the complex are conserved throughout evolution and are also required in the human cells.

Genetic research, RNA processing

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MyoD, modularity, and myogenesis: Conservation of regulators and redundancy in C. elegans

Article Abstract:

The essential role of vertebrate helix-loop-helix (bHLH) transcription factor MyoD family of myogenic regulatory factors (MRFs) in myogenesis and also in muscle specification in Caenorhabditis elegans is discussed. The analysis has suggested that a redundant, modular network controlling myogenesis has allowed dynamic compensation of function, rendering muscle development and also the evolution of different types of muscle.

Muscle proteins, Myogenesis, Structure, Double helix, Report

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