FAR1 links the signal transduction pathway to the cell cycle machinery in yeast
Article Abstract:
The roles of the proteins encoded by the genes FUS3 and FAR1 in the yeast cell cycle were investigated. Previous studies have shown that FUS3, a member of the MAP kinase family, and FAR1, whose molecular activity is unknown, are involved in cell cycle arrest. The results showed that FAR1 is phosphorylated by FUS3, resulting in the former's activation. Activated then FAR1 associates with CDC28-CLN2 kinase in an alpha-factor dependent manner. The results show that FAR1 links the signal transduction pathway to the cell cycle progression machinery, and that FUS3 contributes to cell cycle arrest by activating FAR1.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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MAP kinase pathways in yeast: for mating and more
Article Abstract:
Six established signal transduction pathways such as the pheromone response pathway with MAP kinases (MAPKs) or their upstream regulators are present in the yeast Saccharomyces cerevisiae. Several studies have proved the presence of a new component STE5 that forms the base for the binding of three protein kinases in the MEKK-MEK-MAPK module of the pheromone response pathway. The three main responses in the pheromone response pathway include arrest of cells in G1, transcriptional activation of genes in mating and morphological alteration. The different pathways have modules that vary in their MAPKs.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p
Article Abstract:
Nuclear export of Far1p, a bifunctional protein required to stop the cell cycle and establish cell polarity in yeast mating, in response to pheromones is discussed. The process requires the export receptor Msn5p/Ste21p. It has been shown that Far1p acts in both subcellular compartments with nuclear Far1p necessary to the arrest of the cell cycle. Study results suggest nuclear export of Far1p by Msn5p/Ste21p coordinates the two separable functions of Far1p during mating.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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