FGF-dependent Notch signaling maintains the spinal cord stem zone

Article Abstract:

Generation of the spinal cord relies on proliferation of undifferentiated cells located in a caudal stem zone and a study was conducted to know how fibroblast growth factor (FGF) signaling controls cell behavior. The findings suggest a mechanism for the establishment of the cell selection process, lateral inhibition, mutual inhibition between Delta/Notch-expressing stem zone cells switchers to single Deltal-presenting neurons as FGF activity declines in the newly formed neuroepithelium.

Cell proliferation

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Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling

Article Abstract:

The creation of the in vivo primitive neural stem cell is free from Notch signaling, but the liveliness of the Notch route is significant in transforming the primitive to complete definitive neural stem cells. The foremost neurally identified cell in the epiblast could be the reason for transforming the neutral progenitor cell to the yield neural stem cell or may be the initial neural cell could construct a neural plate prior to the development of definitive neural stem cell.

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Inactivation of TGF(beta) signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome

Article Abstract:

The role of transforming growth factor (TGFbeta) signaling in neural crest stem cells is studied. The result indicates that TGF(Beta) signal modulation in neural crest differentiation may lead to multiple defects, which are indicative of DiGeorge syndrome.

Immunological deficiency syndromes, Immunologic deficiency syndromes, Neural crest

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