Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors

Article Abstract:

Five representative nuclear localizing ligands for which there is documentation of translocation into the cytosol and nucleus through well-characterized pathways is reviewed, in addition to a role in gene activation by ligand/receptor in the nucleus. Interaction of ligands such as epidermal growth factor and interferon-gamma with the extracellular domains of their plasma membrane receptor results in internalization followed by translocation into the nucleus of the ligand.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Medical Research, Epilepsy & Muscle Disease R&D, Administration of Public Health Programs, Health Research Programs, Medicine, Experimental, Epidermal growth factor receptors

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Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance

Article Abstract:

The effects of environmentally responsive molecular chaperone Hsp90 in many proteins and its implications are discussed. It is observed that the storage and release of genetic variation of chaperone mediated proteins lies in the protein folding phenomena, however, to understand the evolutionary process an integration of new ideas with existing paradigms in the protein science is needed.

Genetic variation, Molecular chaperones

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NTE: one target protein for different toxic syndromes with distinct mechanisms?

Article Abstract:

Organophosphates that react with the neuropathy target esterase (NTE), initiate the organophosphates-induced delayed neuropathy epidemic (OPIDN). The various experiments conclude that different toxic syndromes may be initiated via a single target protein.

All Other Basic Organic Chemical Manufacturing, Industrial Organic Chemicals, Organophosphates, Genetic research, Organic phosphorus compounds

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