GAGA mediates the enhancer blocking activity of the "eve" promoter in the Drosophila embryo
Article Abstract:
Genetic research in promoter competition and insulator DNA suggests Trithorax-like-GAGA leads to more stable enhancer-promoter interactions by forming an open chromatin configuration. Drosophila embryos were used to examine even-skipped promoters with insulator activity that can be uncoupled from core elements that mediate competition. TATA has proven essential to promoter competition, while GAGA mediates enhancer blocking.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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A tDNA establishes cohesion of a neighboring silent chromatin domain
Article Abstract:
A study to show that silent chromatin domain is necessary but not sufficient for cohesion of the replicating locus is presented. Results show that a tRNA (tDNA) gene that delimits the silent chromatin domain is also required, as the subunits of the complexes that bind the gene.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner
Article Abstract:
Research has been conducted on the chromatin structure. Results indicate that the protein that has been encoded by proto-oncogene DEK induces alterations of the DNA density in chromatin.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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