Slit is the midline repellent for the Robo receptor in Drosophila
Article Abstract:
Roundabout (Robo) is a repulsive guidance receptor on growth cones in Drosophila that binds to an unidentified midline ligand. A recent study using the Drosophila provided biochemical evidence that identified this unknown midline gland and labeled it slit. Slit was found to be an extracellular matrix protein that is produced by midline glia. Its function s are to act as a short-range repellent controlling axon crossing of the midline and as a long-range chemorepellent controlling mesoderm migration away from the midline.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila
Article Abstract:
The significance of the Drosophila transmembrane protein-tyrosine phosphatase leukocyte common antigen-related (DLAR) in motor axon guidance was studied. Segmental nerve b motor axons in DLAR-deficient embryos, bypassed their muscle destinations. Findings indicated that DLAR regulates the capability of certain motor axons to find their way along certain choice points in the developing Drosophila nervous system.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Crystal structure of the tandem phosphatase domains of RPTP LAR
Article Abstract:
A study was conducted to characterize the structure of the tandem phosphatase domains of receptor-like protein tyrosine phosphatases leukocyte antigen-related (RPTP LAR) proteins. Findings show that the tertiary structure of the LAR D1 and D2 conserved phosphatase domains are almost similar. Their only conformational difference is the presence of two amino acid in the D2 domain.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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