Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
Article Abstract:
The target of Drosophila rapamycin, dTOR, has been identified and characterized genetically and biochemically. It is a candidate effector for nutritional sensing. Genetic and biochemical analyses show that dTOR has an effect on insulin signaling pathways by affecting growth by modulating activity of dS6K autonomously. Partial loss of dTOR activity lowers growth of the endoreplicating tissues preferentially. It appears that dTOR is on a parallel amino acid sensing pathway
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
Article Abstract:
Cellular growth and its regulation by the Drosophila target of rapamycin are discussed. Mutations in the Drosophila TOR homolog, dTOR, were generated, and it was seen that dTOR mutant phenotypes recapitulate aspects of both P13K-dependent signaling and nutritional sensing. That would be consistent with dTOR's acting at the junction of the pathways examined.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
A nutrient sensor mechanism controls Drosophila growth
Article Abstract:
Research shows that organismal growth in Drosophila is initiated by the fat body possessing endocrine and storage functions of the vertebrate liver. Data indicate that the fat body functions as a nutrient sensor and contains slimfast gene whose downregulation leads to a global growth defect similar to that exhibited by Drosophila raised under poor nutritional conditions.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes
- Abstracts: Isolation and characterization of five Erwinia amylovora bacteriophages and assessment of phage resistance in strains of Erwinia amylovora
- Abstracts: Molecular and phenotypic analyses reveal association of diverse Colletotrichum acutatum groups and a low level of C. gloeosporioides with olive anthracnose
- Abstracts: Anaerobic cometabolic conversion of benzothiophene by a sulfate-reducing enrichment culture and in a tar-oil-contaminated aquifer
- Abstracts: The Sinorhizobium meliloti nutrient-deprivation-induced tyrosine degradation gene hmgA is controlled by a novel member of the arsR family of regulatory genes