REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis
Article Abstract:
The transcriptional repressor REST (RE1 silencing transcription factor) regulates the transitions from pluripotent to neural stem/progenitor cell and from progenitor to mature neuron. In the transition to progenitor cell, REST is degraded to levels just sufficient to maintain neuronal gene chromatin in an inactive state that is nonetheless poised for expression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Proline isomerization of histone H3 regulates lysine methylation and gene expression
Article Abstract:
The proline isomerization of histone tails is identified as a novel chromatin modification that controls transcription. An analysis of the FK506 binding protein Fpr4 demonstrates that histones H3 and H4 tails in vitro can be tightly bound by it.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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- Abstracts: Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation
- Abstracts: Control of transcription through intragenic patterns of nucleosome composition. Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation