Control of transcription through intragenic patterns of nucleosome composition

Article Abstract:

Interactions between DNA and histones must be disrupted during transcription initiation so that RNA polymerase access the template strand, providing an opportunity for regulation of transcription initiation through the control of nucleosome stability or positioning at the 5' end of transcription units. It is suggested that 5'-specific and 3'-specific regulation of nucleosome composition and histone modification regulate the location and kinetics of transcriptional initiation in Saccharomyces cerevisiae.

RNA polymerases, Nucleosomes

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Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome

Article Abstract:

A genome-scale approach is used to identify several new components of the pheromone-response pathway and examine whether additional Galpha effectors might exist in yeast. A novel mechanism of G protein-effector interaction is presented in which a Gbeta-like protein (Vps15) exists in a preformed complex with the effector enzyme (Vps34), and Galpha shuttles between these components during the cycle of pathway activation and inactivation.

Analysis, Risk factors, Gene expression, G proteins, Cell hybridization

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Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation

Article Abstract:

Saccharomyces cerevisiae Cth2 protein specifically downregulates mRNAs encoding proteins that participate in many Fe-dependant processes. A study identifies an RNA binding protein, Cth2 that coordinately deregulates the levels of multiple RNAs involved in iron-dependent processes when iron availability is low.

United States, Protein binding, Messenger RNA

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