Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice
Article Abstract:
The hippocampal activity of mutant mice exhibiting CA1 restricted deletion of the N-methyl-D-aspartate receptor subunit 1 (NMDAR1) gene was analyzed by utilizing multielectrode recording techniques. The CA1 restricted NMDAR1 mutants exhibited normal neuronal firing activity characterized by rhythmic modulations of the firing rate with a theta frequency of 8-10 Hertz. However, the NMDAR1 mutants exhibited deficient neuronal firing during the performance of spatial tasks indicating the role of NMDAR1 in spatial memory and synaptic plasticity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory
Article Abstract:
Research has been conducted on the calcium/calmodulin-dependent protein kinase IV. The role of this kinase in the neuronal plasticity and memory has been investigated via the generated transgenic mice with the dominant-negative calcium/calmodulin-dependent protein kinase IV form expression restricted to the postnatal forebrain and the results are presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Translational control by MAPK signaling in long-term synaptic plasticity and memory
Article Abstract:
A study is conducted to investigate the role of MAPK signaling in synaptic plasticity and memory. The results suggest that the translational control by MAPK signaling is crucial in long-lasting forms of synaptic plasticity and memory.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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