Mammalian SIRT1 represses forkhead transcription factors

Article Abstract:

The deacetylation and repression of the activity of forkhead transcription factor - Foxo3a and other mammalian forkhead factors by the mammalian SIR2 ortholog SIRT1 is reported. The speculation over the down regulation of the two classes of damage - responsive mammalian factors, favoring longer life - span under specific environmental conditions is presented.

Genetic transcription, Transcription (Genetics), Cellular control mechanisms, Cell regulation

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Parc: a cytoplasmic anchor for p53

Article Abstract:

Research has been conducted on Parkin-like ubiquitin ligase Parc. The authors report the identification of Parc as cytoplasmic anchor protein in p53-associated protein complexes, and inform that this protein regulates p53 subcellular localization and function.

Physiological aspects, Membrane proteins, Genetic regulation, Cell research, Cytological research, Ligases, Cytoplasm

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Negative control of p53 by Sir2alpha promotes cell survival under stress

Article Abstract:

Results demonstrate that mammalian Sir2alpha interacts with p53 inhibiting deacetylation of p53 as well as enhancing acetylation of p53 in vivo. Data also suggest that Sir2alpha represses p53-dependent apoptosis during DNA damage and oxidative stress.

Research, Cell death, Stress (Physiology), Tumor suppressor genes, Cell metabolism

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