Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival

Article Abstract:

Evidence of a genetic nature for a role for Src family kinases in cell survival and tumor necrosis factor (TNF) family receptor signaling has been found. Mutant src -/- mice exhibit osteopetrosis from defective osteoclasts, but signaling pathways involving Src family members in osteoclasts have not been clear. The expression of a truncated Src molecule, Src251, which does not have the kinase domain, brings on osteopetrosis in wild-type and src +/- mice. It makes osteopetrosis in src -/- mice worse by upping osteoclast apoptosis.

Bones, Growth, Cellular signal transduction, Mice, mutant strains, Mutant mice, Tumor necrosis factor, Bone development, Osteopetrosis

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Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

Article Abstract:

Selective induction of E2F1 from DNA damage has been found to be mediated by ATM-dependent phosphorylation. A site for ATM/ATR phosphorylation in the amino terminus of E2F1 is necessary for apoptosis in mouse thymocytes brought on by DNA damage. ATM/ATR is a kinase that activates p53 as a response to DNA damage.

DNA damage, Phosphorylation, Tumors

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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

Article Abstract:

Induction and apoptotic regression of lung adenocarcinomas with/without tumor suppressor genes by regulation of a K-Ras transgene is discussed. A transgenic mouse that expresses murine K-Ras4b(superG12D) under the control of doxycycline in type II pneumocytes was developed. Appearance and regression of the pulmonary tumors in question can be monitored in anesthetized transgenic animals using MRI.

Magnetic resonance imaging, Tumor suppressor genes, Lung cancer, Doxycycline, Tetracycline, Tetracyclines

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