Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
Article Abstract:
Inflammatory mast cells have been found to up-regulate angiogenesis in squamous epithelial carcinogenesis. Infiltration by mast cells and activation of the matrix metalloproteinase MMP-9/gelatinase B comes with the angiogenic changeover in lesions not yet malignant. Regulation of angiogenesis in this situation is biphasic. In hyperplasias, invading cancer fronts, and dysplasias inflammatory mast cells are drafted to hyperacitivate angiogenesis and reorganize stromal architecture. In the cancer core, up-regulation of angiogenesis factors in tumor cells seems to make them self-sufficient for sustaining neovascularization.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Matrix metalloproteinases: effectors of development and normal physiology
Article Abstract:
Matrix metalloproteinases (MMPs) are discussed as effectors of development and normal physiology in this review article. Topics include cell migration, tissue morphogenesis, extracellular matrix (ECM)-dependent cell proliferation and apoptosis, modulation of biologically active molecules, implantation, wound healing, mammary development, and bone development. MMPs are a family of extracellular proteinases sharing common functional domains and activation mechanisms.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
Article Abstract:
Skeletal growth plate vascularization and ossification in homozygous mice was observed to be abnormal due to a null mutation in the MMP-9/gelatinase B gene. However, the delays in vascularization and ossification stopped following the transplantation of wild-type bone marrow cells. Gelatinase B-expressing cells may have a role in controlling angionesis via a delay in the release of an angiogenic activator.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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