Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer
Article Abstract:
The protein interaction network involved in suppressing homologous recombination within the rDNA locus is analyzed using affinity purification combined with highly sensitive mixture mass spectrometry. A model is suggested in which regulator of nucleolar silencing and telophase exit [RENT], Tof2 and Lrs4/Csm1 physically clamp rDNA to the cohesin ring, thereby restricting the movement of rDNA sister chromatids relative to each other to inhibit unequal exchange.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
Article Abstract:
The paper elucidates function of one of the transcriptional silencing proteins Sir2 in yeast. Results demonstrate that Sir2 exhibits an ADP-ribosyltransferase activity that is essential for gene silencing activity and mediates phosphate transfer to itself and to histones in vitro.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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