Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70
Article Abstract:
A major cellular protein associated with endogenous WT1 has been identified by immunoprecipitation and protein microsequencing analysis as the inducible chaperone Hsp70. WT1, the Wilms tumor suppressor, codes a zinc finger transcription factor expressed in glomerular podocytes during a short time period in kidney development. WT1 and Hsp70 are close in primary Wilms tumor specimens, in rat embryo kidney cells, and in cells in culture with inducible expression of WT1. It appears that Hsp70 is an important cofactor for WT1 and that the chaperone may be a factor during kidney differentiation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
The bloody fate of endothelial stem cells
Article Abstract:
Thw authors review the publications on endothelial cells. The topics of interest include capturing elusive endothelial cells, and transcriptional programming of hematopoietic development.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Reductive dehalogenation of brominated phenolic compounds by microorganisms associated with the marine sponge Aplysina aerophoba
- Abstracts: Factors affecting the determination of respiratory activity on the basis of cyanoditolyl tetrazolium chloride reduction with membrane filtration
- Abstracts: Effect on P availability on temporal dynamics of carbon allocation and Glomus intraradices high-affinity P transporter gene induction in arbuscular mycorrhiza
- Abstracts: An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Dkk1 and noggin cooperate in mammalian head induction